HSP90 Controls SIR2 Mediated Gene Silencing
نویسندگان
چکیده
منابع مشابه
HSP90 Controls SIR2 Mediated Gene Silencing
In recent years, Hsp90 is found to interact with several telomeric proteins at various phases of cell cycle. The Hsp90 chaperone system controls assembly and disassembly of telomere structures and thus maintains the dynamic state of telomere. Here, for the first time we report that the activity of another telomeric protein Sir2p is modulated by Hsp82, the ortholog of Hsp90 from budding yeast (S...
متن کاملGene silencing: Two faces of SIR2
There are still many mysteries surrounding how silenced regions of the eukaryotic genome are created and maintained. But recent discoveries about the most evolutionarily conserved silencing protein, Sir2p, have provided new mechanistic insights into these processes.
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Aging is manifested by a progressive decline in vitality over time leading to death. Studies in budding yeast allow aging to be followed in individual pedigrees of cells, that is, those of mother cells, consequent to many rounds of cell division (Mortimer and Johnston 1959). These studies have led to the general conclusion that the silencing protein Sir2 is a limiting component of longevity; de...
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Heritable domains of generalized repression are a common feature of eukaryotic chromosomes and involve the assembly of DNA into a silenced chromatin structure. Sir2, a conserved protein required for silencing in yeast, has recently been shown to couple histone deacetylation to cleavage of a high-energy bond in nicotinamide adenine dinucleotide (NAD) and the synthesis of a novel product, O-acety...
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The Alu elements are conserved approximately 300-nucleotide-long repeat sequences that belong to the SINE family of retrotransposons found abundantly in primate genomes. Pairs of inverted Alu repeats in RNA can form duplex structures that lead to hyperediting by the ADAR enzymes, and at least 333 human genes contain such repeats in their 3'-UTRs. Here, we show that a pair of inverted Alus place...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0023406